Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Madrid (South) | Südseite Hauptbahnhof | Cheapest | |||||
| Madrid (South) | Südseite Hauptbahnhof | Fastest | |||||
| Madrid (South) | Südseite Hauptbahnhof | No tags | |||||
Flixbus + Flixtrain | Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4 | Karlsruhe Hbf | No tags | |||||
| Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4 | Südseite Hauptbahnhof | No tags |
Last refresh of the prices: Today at 9:03 AM CET.
Get from Madrid to Karlsruhe
The journey takes about 1 day, 2 hours 15 minutes, and with fares starting at just $109, it presents an excellent value for a comfortable ride.
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Where are the popular stops in Madrid and Karlsruhe?
Frequently asked questions about travelling from Madrid to Karlsruhe by bus
What is the travel distance from Madrid to Karlsruhe?
It's about 1350 km (837 miles) from Madrid to Karlsruhe.
What are the departure and arrival locations for buses traveling from Madrid to Karlsruhe?
Buses departing from Estación Sur in Madrid will take you to Südseite Hauptbahnhof in Karlsruhe.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Madrid to Karlsruhe was searched and found on Nov 21, 2025 with a price of $104To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Madrid to Karlsruhe, as early as possible.
You can expect to pay from $104 to $306 for a bus ticket from Madrid to Karlsruhe based on the last 2 days. You can expect to find the cheapest price for the trip at $104 which is on 2025-11-21.
