Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Bus Station | CheapestFastest |
Last refresh of the prices: Yesterday at 10:12 PM EST.
Get from Knoxville to Myrtle Beach
The journey takes about 21 hours 40 minutes, and with fares starting at just $399, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Myrtle Beach?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87503 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $399
Frequently asked questions about travelling from Knoxville, TN to Myrtle Beach by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Myrtle Beach?
The cheapest bus tickets from Knoxville to Myrtle Beach start from $399. The average price for this route is around $399. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Myrtle Beach?
The average bus travel time from Knoxville to Myrtle Beach is 21h 40m, covering a distance of 523 km. The quickest bus can get you there in 21h 40m and is operated by Greyhound.
Which bus companies service the Knoxville to Myrtle Beach route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Knoxville to Myrtle Beach?
The earliest bus departs from Knoxville to Myrtle Beach at 6:10pm. And the latest bus departs at 7:05pm.
What are the CO₂ emissions for the bus trip from Knoxville to Myrtle Beach?
A bus trip from Knoxville to Myrtle Beach generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Myrtle Beach was searched and found on Jan 16, 2026 with a price of $290To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Myrtle Beach, as early as possible.
