Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | 1116 Woodruff Rd | CheapestFastest |
Last refresh of the prices: Yesterday at 11:16 PM EST.
Get from Knoxville to Greenville
The journey takes about 11 hours 25 minutes, and with fares starting at just $102, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Greenville?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Based on 87518 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at $102
Frequently asked questions about travelling from Knoxville, TN to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Greenville?
The cheapest bus tickets from Knoxville to Greenville start from $102. The average price for this route is around $158. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Greenville?
The average bus travel time from Knoxville to Greenville is 11h 25m, covering a distance of 193 km. The quickest bus can get you there in 11h 25m and is operated by Greyhound.
Which bus companies service the Knoxville to Greenville route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Knoxville to Greenville?
The earliest bus departs from Knoxville to Greenville at 6:10pm. And the latest bus departs at 7:40pm.
What are the CO₂ emissions for the bus trip from Knoxville to Greenville?
A bus trip from Knoxville to Greenville generates an estimated 5 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Greenville, SC was searched and found on Jan 29, 2026 with a price of $76To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Greenville, SC, as early as possible.
You can expect to pay from $76 to $135 for a bus ticket from Knoxville, TN to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $128 which is on 2026-02-01.
