Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Knoxville Bus Station | 537-517 W. Jackson Blvd | Fastest | ||||
| Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags | ||||
| Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags |
Last refresh of the prices: Yesterday at 11:58 AM EST.
Get from Knoxville to Chicago
The journey takes about 17 hours 30 minutes, and with fares starting at just $106, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Chicago?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Based on 87396 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $177
Greyhound Knoxville Chicago recent customer reviews
the bus was supposed to leave Knoxville at 7:10 pm but left at 10:00 pm. We didn't know when the bus would leave, we got a lot of stress. In addition, there is no bus station building in Knoxville and we were on the street all this time. Since the bus left late, I missed my bus from Nashville to Chicago. and instead of arriving in Chicago at 8:35 am, I arrived at 1:00 pm. I wrote to the support service, I wanted to return the ticket due to the bus being late and fly by plane, but they answered me with automatic messages. the bus was supposed to leave Knoxville at 7:10 pm but left at 10:00 pm. We didn't know when the bus would leave, we got a lot of stress. In addition, there is no bus station building in Knoxville and we were on the street all this time. Since the bus left late, I missed my bus from Nashville to Chicago. and instead of arriving in Chicago at 8:35 am, I arrived at 1:00 pm. and I also didn’t like that they woke me up and kicked me off the bus at every stop
Artur T.
We were waylaid for an incredible 7 hours between Knoxville and Nashville because of an extremely suspect technical issue regarding the brightness of headlights. During this time a customer, understandably dissatisfied with the ride and the information given to them, expressed this to the driver whereupon the driver called the police on the passenger who was escorted off the bus by cops. Following our arrival into Knoxville we were again delayed when, due to understaffing, we were unable to get our redirected tickets in time. The actual ticketing staff at the Nashville terminal is the only reason the employees get 2 stars. He deserves a raise and probably a better job. Finally, after everything was sorted and we made our way into Chicago, our luggage went untransfered in Indianapolis and we had to return to get it the next day. This was a nightmarish ordeal and I will, from here on out, be spending my money on alternative methods of transportation.
Willem D.
It took us to get to home 24hrs instead 12 hrs with additional cost of $230 due to delay and no bus available at connections.
Nareshkumar P.
Frequently asked questions about travelling from Knoxville, TN to Chicago by bus
What is the distance between Knoxville and Chicago?
The distance covered from Knoxville to Chicago is 731 km (454 miles).
What are the departure and arrival locations for buses traveling from Knoxville to Chicago?
Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Downtown Greyhound Station, in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Chicago was searched and found on Nov 27, 2025 with a price of $215To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Chicago, as early as possible.
You can expect to pay from $215 to $499 for a bus ticket from Knoxville, TN to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $215 which is on 2025-11-27.
