Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines | MLK Transportation Center | CheapestFastest |
Last refresh of the prices: Yesterday at 4:14 PM CST.
Get from Des Moines to Sioux City
The journey takes about 4 hours 5 minutes, and with fares starting at just $144, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Sioux City?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Sioux City
- A
W Maple St
4110 W Maple St, Sioux Falls, SD 57107, USA
Compare bus companies
Based on 759 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the seats but often complained with the WiFi. Jefferson Lines ticket prices on this trip start at $144
Frequently asked questions about travelling from Des Moines to Sioux City by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Sioux City?
The cheapest bus tickets from Des Moines to Sioux City start from $144. The average price for this route is around $159. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Sioux City?
The average bus travel time from Des Moines to Sioux City is 4h 5m, covering a distance of 252 km. The quickest bus can get you there in 3h 55m and is operated by Jefferson Lines.
Which bus companies service the Des Moines to Sioux City route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Des Moines to Sioux City?
The earliest bus departs from Des Moines to Sioux City at 3:45am. And the latest bus departs at 6:15pm.
What are the CO₂ emissions for the bus trip from Des Moines to Sioux City?
A bus trip from Des Moines to Sioux City generates an estimated 6 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Sioux City was searched and found on Nov 28, 2025 with a price of $154To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Sioux City, as early as possible.
