What is the distance between Charleston and Jacksonville?

It's about 318 km (198 miles) from Charleston to Jacksonville.

What are the departure and arrival locations for buses traveling from Charleston to Jacksonville?

Buses departing from Charleston Bus Station in Charleston will take you to Jacksonville Amtrak Station in Jacksonville.

Bus Charleston to Jacksonville from $50 | Refundable Tickets

Next bus departures

Next departures for Charleston to Jacksonville on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
Greyhound Lines, Inc. + FlixBus	Bus	11:15am	4565 Gaynor Ave, North Charleston	10h 10m	9:25pm	Jacksonville Bus Station	CheapestFastest

Next departures for Charleston to Jacksonville on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
Greyhound Lines, Inc. + FlixBus	Bus	11:15am	4565 Gaynor Ave, North Charleston	10h 10m	9:25pm	Jacksonville Bus Station	CheapestFastest

Next departures for Charleston to Jacksonville on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
Greyhound Lines, Inc. + FlixBus	Bus	11:15am	4565 Gaynor Ave, North Charleston	10h 10m	9:25pm	Jacksonville Bus Station	CheapestFastest

Next departures for Charleston to Jacksonville on November 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
Greyhound Lines, Inc. + FlixBus	Bus	11:15am	4565 Gaynor Ave, North Charleston	10h 10m	9:25pm	Jacksonville Bus Station	CheapestFastest

Next departures for Charleston to Jacksonville on November 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
Greyhound Lines, Inc. + FlixBus	Bus	11:15am	4565 Gaynor Ave, North Charleston	10h 10m	9:25pm	Jacksonville Bus Station	CheapestFastest

Next departures for Charleston to Jacksonville on November 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
Greyhound Lines, Inc. + FlixBus	Bus	11:15am	4565 Gaynor Ave, North Charleston	10h 10m	9:25pm	Jacksonville Bus Station	CheapestFastest

Next departures for Charleston to Jacksonville on November 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
Greyhound Lines, Inc. + FlixBus	Bus	11:15am	4565 Gaynor Ave, North Charleston	10h 10m	9:25pm	Jacksonville Bus Station	CheapestFastest

Last refresh of the prices: Yesterday at 5:28 PM EST.

Compare 2 ways to go from Charleston to Jacksonville

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Jacksonville. The journey takes about 5 hours 28 minutes, and with fares starting at just $74, it presents an excellent value for a comfortable ride.

2train per day

5h 28mAverage Duration

324 kmDistance

29kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$50 - $150	Average Duration9h 50m	CO₂ emissions 8kg CO₂e
Train	Average Price$74 - $221	Average Duration5h 28m	CO₂ emissions 29kg CO₂e

Where are the popular stops in Charleston and Jacksonville?

Stops in Charleston

A
Charleston Bus Station
3610 Dorchester Rd, North Charleston, SC 29405

Stops in Jacksonville

A
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA
Visit page
B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA
C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207
D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA

Compare bus companies

FlixBus

3.5/511,411 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Greyhound

3.5/587,391 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Charleston, SC, US to Jacksonville, FL by bus

What is the distance between Charleston and Jacksonville?
It's about 318 km (198 miles) from Charleston to Jacksonville.
What are the departure and arrival locations for buses traveling from Charleston to Jacksonville?
Buses departing from Charleston Bus Station in Charleston will take you to Jacksonville Amtrak Station in Jacksonville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-21

$58

11-22

$58

Today

$68

11-24

$64

11-25

$70

11-26

$81

11-27

$73

11-28

$68

The cheapest trip from Charleston, SC, US to Jacksonville, FL was searched and found on Nov 21, 2025 with a price of $58

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston, SC, US to Jacksonville, FL, as early as possible.

You can expect to pay from $58 to $81 for a bus ticket from Charleston, SC, US to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $64 which is on 2025-11-24.