Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Calexico Bus Station | UC Irvine (Crawford Hall) | No tags | ||||
Greyhound + FlixBus | Bus | Calexico Bus Station | Santa Ana Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | Calexico Bus Station | Anaheim Regional Transportation Intermodal Center | No tags | ||||
 | Bus | Calexico Bus Station | Santa Ana Bus Station | No tags | ||||
| Bus | Calexico Bus Station | Anaheim Regional Transportation Intermodal Center | No tags |
Get from Calexico to Santa Ana
The journey takes about 7 hours 10 minutes, and with fares starting at just $63, it presents an excellent value for a comfortable ride.
Where are the popular stops in Calexico and Santa Ana?
Stops in Calexico
- A
Calexico Bus Station
123 E 1st St, Calexico, CA 92231 - B
Calexico
498 W 2nd St, Calexico, CA 92231, USA
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
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Frequently asked questions about travelling from Calexico to Santa Ana, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Calexico to Santa Ana?
The cheapest bus tickets from Calexico to Santa Ana start from $63. The average price for this route is around $84. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Calexico to Santa Ana?
The average bus travel time from Calexico to Santa Ana is 7h 10m, covering a distance of 251 km. The quickest bus can get you there in 6h 35m and is operated by Greyhound.
Which bus companies service the Calexico to Santa Ana route?
What are the earliest and latest departure times for the bus from Calexico to Santa Ana?
The earliest bus departs from Calexico to Santa Ana at 8:10am. And the latest bus departs at 2:45pm.
What are the CO₂ emissions for the bus trip from Calexico to Santa Ana?
A bus trip from Calexico to Santa Ana generates an estimated 6 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Calexico to Santa Ana?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Calexico to Santa Ana?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Calexico to Santa Ana?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Calexico to Santa Ana?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Calexico to Santa Ana, US was searched and found on Dec 2, 2025 with a price of $58To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Calexico to Santa Ana, US, as early as possible.
You can expect to pay from $58 to $144 for a bus ticket from Calexico to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $58 which is on 2025-12-02.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
