Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Brookline | Gateway Station | Cheapest | ||||
 | Bus | Boston (South Station) | Gateway Station | Fastest | ||||
| Bus | Boston (South Station) | Gateway Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Brookline | Gateway Station | No tags | ||||
| Bus | Boston (South Station) | Gateway Station | No tags |
Last refresh of the prices: Today at 2:09 PM EST.
Compare 2 ways to go from Boston to St. Louis
Among the sustainable travel choices, the Bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 7 hours 25 minutes, and with fares starting at just $145, it presents an excellent value for a comfortable ride.
Where are the popular stops in Boston and St. Louis?
Stops in Boston
- A145 Dartmouth St, Boston, MA 02116, USA
- B100 Legends Way, Boston, MA 02114, USA
- C335 Grove St, Auburndale, MA 02466
- D
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA - E
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA - F
Long Wharf
66 Long Wharf, Boston, MA 02110, USA
Compare bus companies
Frequently asked questions about travelling from Boston, MA, US to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Boston to St. Louis?
The cheapest bus tickets from Boston to St. Louis start from $145. The average price for this route is around $252. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Boston to St. Louis?
The average bus travel time from Boston to St. Louis is 1d 7h, covering a distance of 1668 km. The quickest bus can get you there in 1d 4h and is operated by Greyhound.
Which bus companies service the Boston to St. Louis route?
What are the earliest and latest departure times for the bus from Boston to St. Louis?
The earliest bus departs from Boston to St. Louis at 1:30am. And the latest bus departs at 9:50pm.
What are the CO₂ emissions for the bus trip from Boston to St. Louis?
A bus trip from Boston to St. Louis generates an estimated 42 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Boston to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from Boston to St. Louis?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Boston to St. Louis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Boston to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Boston, MA, US to St. Louis was searched and found on Jan 7, 2026 with a price of $158To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to St. Louis, as early as possible.
You can expect to pay from $158 to $401 for a bus ticket from Boston, MA, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $158 which is on 2026-01-12.
What's the cheapest way to go from Boston, MA, US to St. Louis?
The Bus is the cheapest travel choice for this destination
