Trains tickets from Florence (SC), US to Buffalo (NY)

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TodayMay 17
TomorrowMay 18
MonMay 19
TueMay 20
WedMay 21
ThuMay 22
from $290
FriMay 23
SatMay 24

Trains leaving Thursday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: May 22 at
    Departure city: Florence
    Departure location: Florence Station
    Arrival time: May 24 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:
  • Departure time: May 22 at
    Departure city: Florence
    Departure location: Florence Station
    Arrival time: May 24 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: TrainDuration:

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Compare 2 ways to go from Florence to Buffalo.

Bus
Average Price$171 - $323Average Duration1d
24kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$227 - $484Average Duration22h 10m
88kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Florence to Buffalo

Among the sustainable travel choices, the train stands out as the good way to reach Buffalo. The journey takes about 22 hours 10 minutes and with fares starting at just $227, it presents an excellent value for a comfortable ride.

3train per day
22h 10mAverage Duration
$227Cheapest ticket
88kgCO₂ emissions

Train Florence to Buffalo: Trip Overview

Please note, this information is subject to change.

Average ticket price$259
Average train trip duration22h 10m
Number of daily trains3
Earliest train departure11:32pm
Distance601 miles (968 km)

Florence to Buffalo Train

Busbud shows you the best train ticket fares and train schedules so you can easily plan and book a trip by train from Florence to Buffalo.

We make it our job to connect you with the most dependable companies that offer train service from Florence to Buffalo.

Whether it is train tickets or first class train tickets going to Buffalo from Florence, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Florence - Buffalo

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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05/22
$290
busbud logoThe cheapest trip from Florence to Buffalo was searched and found on May 22, 2025 with a price of $290

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Florence to Buffalo, as early as possible.

You can expect to pay from $290 to $761 for a train ticket from Florence to Buffalo based on the last 2 days. You can expect to find the cheapest price for the trip at $290 which is on 2025-05-22.

About Train Travel

Train Travel Tips

Do you like to go fast? With high-speed trains going faster than 300 km/h on certain routes, the time will fly by. Taking a train between Florence and Buffalo is also a great way to travel to arrive in the city centre and save more time for your stay in Buffalo.

Whether you take a regional or high-speed train to Buffalo, you’ll help reduce the environmental impact and carbon footprint of your trip. As you watch the landscapes unfold before your eyes, you can tell yourself that with this choice, you are making sure they remain protected.

By choosing the train between Florence and Buffalo, you emit up to 30 times less CO2 than for the same journey made by plane or car!

Tune out to the fine sounds of your best music playlist on your train trip from Florence to Buffalo while indulging in miles on end of beautiful scenic views.

Did you know?

The first high-speed train line was inaugurated in 1964, in Japan, to connect Tokyo with Osaka. It was during the Olympics that the first passengers traveled aboard the Shinkansen at a speed of 210 km / h.

You can find the straightest railway in the world in Australia. This railway line is 478 kilometres long and is also considered the longest and straightest railway line in the world.

Railway companies played a major role as early as 1883 in the use of time zones as we know them today.

Will you be returning to Florence by train?

Train from Buffalo to Florence

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