Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Mesa Bus Stop | Daly BART - 500 John Daly Blvd | No tags | ||||
FlixBus + Greyhound | Bus | Mesa Bus Stop | 409 Townsend St, SF | No tags | ||||
 | Bus | Mesa Bus Stop | San Francisco Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | Mesa Bus Stop | 409 Townsend St, SF | No tags | ||||
| Bus | Mesa Bus Stop | San Francisco Bus Station | No tags |
Get from Mesa to San Francisco
The journey takes about 21 hours 55 minutes, and with fares starting at just £128, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and San Francisco?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Stops in San Francisco
- A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA - B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812 - C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114 - D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105 - E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA
Compare bus companies
Based on 87516 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £162
Frequently asked questions about travelling by bus from Mesa to San Francisco, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Mesa to San Francisco?
The cheapest coach tickets from Mesa to San Francisco start from £128. The average price for this route is around £169. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Mesa to San Francisco?
The average bus journey time from Mesa to San Francisco is 21h 55m, covering a distance of 665 miles. The fastest bus can take you there in 17h 30m and is operated by Greyhound.
Which bus companies service the Mesa to San Francisco route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Mesa to San Francisco?
The earliest bus departs from Mesa to San Francisco at 14:45. And the latest bus departs at 21:10.
What are the CO₂ emissions for the bus trip from Mesa to San Francisco?
A bus journey from Mesa to San Francisco produces an estimated 27 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to San Francisco, US was searched and found on 20 Jan 2026 with a price of £179To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to San Francisco, US as early as possible.
You can expect to pay from £179 to £220 for a bus ticket from Mesa to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at £220, which is on 2026-01-22.
