Previously seen journeys

Next departures from Syracuse to Florence on 23 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	09:25	Syracuse (Regional Transportation Center)	20h 10m	05:35	Florence, SC	No tags
Greyhound + FlixBus	Bus	21:00	Syracuse (Regional Transportation Center)	1d 8h	05:35	Florence, SC	No tags
Greyhound + FlixBus	Bus	15:00	Syracuse (Regional Transportation Center)	21h 45m	12:45	Bus station	No tags
FlixBus + Greyhound	Bus	21:00	Syracuse (Regional Transportation Center)	1d 8h	05:45	Florence, SC	No tags
Greyhound + FlixBus	Bus	09:25	Syracuse (Regional Transportation Center)	20h 20m	05:45	Florence, SC	No tags

Compare 2 ways to travel from Syracuse to Florence

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 20 hours 45 minutes and with fares starting at just £121, it presents an excellent value for a comfortable ride.

3bus per day

20h 45mAverage duration

642 milesDistance

26kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average price£121 - £315	Average duration20h 45m	CO₂ emissions 26kg CO₂e
Train	Average price£226 - £1,067	Average duration20h 4m	CO₂ emissions 94kg CO₂e

Where are the popular stops in Syracuse and Florence?

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
Visit page
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

20/12

No data

21/12

No data

Today

No data

23/12

£290

24/12

No data

25/12

No data

26/12

No data

27/12

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The cheapest trip from Syracuse, US to Florence, SC, US was searched and found on 23 Dec 2025 with a price of £290

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Florence, SC, US as early as possible.

You can expect to pay from £290 to £290 for a bus ticket from Syracuse, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at £290, which is on 2025-12-23.