Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Sioux Falls | Des Moines | Cheapest | ||||
| Bus | Sioux Falls | Des Moines | Fastest |
Last refresh of the prices: Yesterday at 19:10 CST.
Get from Sioux Falls to Des Moines
The journey takes about 16 hours 55 minutes, and with fares starting at just £129, it presents an excellent value for a comfortable ride.
Where are the popular stops in Sioux Falls and Des Moines?
Stops in Sioux Falls
- A
Jefferson Lines Station I-29 & Maple St
4101 W Maple St, Sioux Falls, SD 57107, USA
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Compare bus companies
Based on 766 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Jefferson Lines ticket prices on this trip start at £129
Frequently asked questions about travelling by bus from Sioux Falls to Des Moines
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Sioux Falls to Des Moines?
The cheapest coach tickets from Sioux Falls to Des Moines start from £129. The average price for this route is around £129. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Sioux Falls to Des Moines?
The average bus journey time from Sioux Falls to Des Moines is 16h 55m, covering a distance of 211 miles. The fastest bus can take you there in 12h 40m and is operated by Jefferson Lines.
Which bus companies service the Sioux Falls to Des Moines route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Sioux Falls to Des Moines?
The earliest bus departs from Sioux Falls to Des Moines at 10:00. And the latest bus departs at 19:00.
What are the CO₂ emissions for the bus trip from Sioux Falls to Des Moines?
A bus journey from Sioux Falls to Des Moines produces an estimated 8 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Sioux Falls to Des Moines was searched and found on 29 Jan 2026 with a price of £125To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Sioux Falls to Des Moines as early as possible.
You can expect to pay from £125 to £134 for a bus ticket from Sioux Falls to Des Moines based on the last 2 days. You can expect to find the cheapest price for the trip at £125, which is on 2026-01-31.
