Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Chicago 95Th & Dan Ryan | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Chicago 95Th & Dan Ryan | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Downtown Greyhound Station | No tags | ||||
 | Bus | Panama City Beach Station | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Downtown Greyhound Station | No tags |
Last refresh of the prices: Last Tuesday at 18:30 CST.
Get from Panama City to Chicago
The journey takes about 1 day, 6 hours 40 minutes, and with fares starting at just £106, it presents an excellent value for a comfortable ride.
Where are the popular stops in Panama City and Chicago?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Based on 87508 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £115
Frequently asked questions about travelling by bus from Panama City, US to Chicago
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Panama City to Chicago?
The cheapest coach tickets from Panama City to Chicago start from £106. The average price for this route is around £173. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Panama City to Chicago?
The average bus journey time from Panama City to Chicago is 1d 6h, covering a distance of 813 miles. The fastest bus can take you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Panama City to Chicago route?
Several major bus companies operate on this route with 9 buses available per day.
What is the earliest and latest departure time for the bus from Panama City to Chicago?
The earliest bus departs from Panama City to Chicago at 07:30. And the latest bus departs at 21:40.
What are the CO₂ emissions for the bus trip from Panama City to Chicago?
A bus journey from Panama City to Chicago produces an estimated 33 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City, US to Chicago was searched and found on 18 Jan 2026 with a price of £128To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Chicago as early as possible.
You can expect to pay from £128 to £198 for a bus ticket from Panama City, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £195, which is on 2026-01-19.
