Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | St. Paul & N5th | Sioux Falls | CheapestFastest |
Last refresh of the prices: Today at 16:06 CST.
Get from Milwaukee to Sioux Falls
The journey takes about 1 day, 45 minutes, and with fares starting at just £154, it presents an excellent value for a comfortable ride.
Where are the popular stops in Milwaukee and Sioux Falls?
Stops in Milwaukee
- B433 W St Paul Ave, Milwaukee, WI 53203, USA
- C
S Cesar Chavez
1016 S Cesar E Chavez Dr, Milwaukee, WI 53204, USA
Stops in Sioux Falls
- A
Jefferson Lines Station I-29 & Maple St
4101 W Maple St, Sioux Falls, SD 57107, USA
Compare bus companies
Based on 761 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the value for money but often complained with the Wi-Fi. Jefferson Lines ticket prices on this trip start at £154
Frequently asked questions about travelling by bus from Milwaukee to Sioux Falls
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Milwaukee to Sioux Falls?
The cheapest coach tickets from Milwaukee to Sioux Falls start from £154. The average price for this route is around £154. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Milwaukee to Sioux Falls?
The average bus journey time from Milwaukee to Sioux Falls is 1d , covering a distance of 446 miles. The fastest bus can take you there in 1d and is operated by Jefferson Lines.
Which bus companies service the Milwaukee to Sioux Falls route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Milwaukee to Sioux Falls?
The earliest bus departs from Milwaukee to Sioux Falls at 09:00. And the latest bus departs at 09:00.
What are the CO₂ emissions for the bus trip from Milwaukee to Sioux Falls?
A bus journey from Milwaukee to Sioux Falls produces an estimated 18 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milwaukee to Sioux Falls was searched and found on 26 Dec 2025 with a price of £150To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to Sioux Falls as early as possible.
You can expect to pay from £150 to £150 for a bus ticket from Milwaukee to Sioux Falls based on the last 2 days. You can expect to find the cheapest price for the trip at £150, which is on 2025-12-27.
