Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines | Sioux Falls | CheapestFastest | ||||
| Bus | Des Moines | Sioux Falls | No tags |
Last refresh of the prices: Today at 06:07 CST.
Get from Des Moines to Sioux Falls
The journey takes about 14 hours 20 minutes, and with fares starting at just £93, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Sioux Falls?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Sioux Falls
- A
Jefferson Lines Station I-29 & Maple St
4101 W Maple St, Sioux Falls, SD 57107, USA
Compare bus companies
Based on 766 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Jefferson Lines ticket prices on this trip start at £93
Frequently asked questions about travelling by bus from Des Moines to Sioux Falls
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Des Moines to Sioux Falls?
The cheapest coach tickets from Des Moines to Sioux Falls start from £93. The average price for this route is around £129. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Des Moines to Sioux Falls?
The average bus journey time from Des Moines to Sioux Falls is 14h 20m, covering a distance of 211 miles. The fastest bus can take you there in 6h and is operated by Jefferson Lines.
Which bus companies service the Des Moines to Sioux Falls route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Des Moines to Sioux Falls?
The earliest bus departs from Des Moines to Sioux Falls at 00:01. And the latest bus departs at 18:50.
What are the CO₂ emissions for the bus trip from Des Moines to Sioux Falls?
A bus journey from Des Moines to Sioux Falls produces an estimated 8 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Sioux Falls was searched and found on 31 Jan 2026 with a price of £91To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Sioux Falls as early as possible.
You can expect to pay from £91 to £126 for a bus ticket from Des Moines to Sioux Falls based on the last 2 days. You can expect to find the cheapest price for the trip at £91, which is on 2026-01-31.
