Find coaches from Des Moines to San Diego (CA), US

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Today16 Jun
Tomorrow17 Jun
from US$276
Wed18 Jun
Thu19 Jun
Fri20 Jun
Sat21 Jun
Sun22 Jun
Mon23 Jun

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 17 June at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: 20 June at
    Destination city: San Diego
    Destination location: 5716 Hardy Ave
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 17 June at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: 19 June at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 17 June at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: 19 June at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 17 June at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: 19 June at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 17 June at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: 19 June at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Bus Des Moines to San Diego: Trip Overview

Average ticket priceUS$302
Average bus trip duration2d 18h
Number of daily buses6
Earliest bus departure05:30
Distance1420 miles

Des Moines to San Diego Bus

Busbud helps you find a bus from Des Moines to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Des Moines to San Diego from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Des Moines to San Diego, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Des Moines - San Diego (CA), US

  1. How much does a coach ticket from Des Moines to San Diego cost?

    For coach travel from Des Moines to San Diego, ticket prices typically start at US$3 and can reach a maximum of US$4. The cost of tickets can fluctuate based on factors like the time of day, the company, and the class you choose. Use Busbud to compare prices and amenities offered by different companies, ensuring you find the most favorable deals and promotions.

  2. How long does the coach from Des Moines to San Diego take?

    The average duration for a trip from Des Moines to San Diego by coach is around 2d 18h. If you're looking for the fastest trip, you can get there in just about 2d 14h. Please be aware that the time it takes for your journey may vary depending on the traffic conditions along the route.

  3. At what time does the first coach from Des Moines to San Diego leave?

    The first coach to San Diego from Des Moines departs at 05:30. Times and services may vary during weekends and holidays.

  4. What's the distance between Des Moines and San Diego by coach?

    The distance between Des Moines and San Diego by coach is approximately 1427 miles (2302 km).

  5. How can I travel from Des Moines to San Diego avoiding air travel?

    You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.

  6. Can I catch a night coach from Des Moines to San Diego?

    You can hop on coaches departing from Des Moines until 05:30 and reaching San Diego the following day. Make sure to bring a snack and a blanket to keep yourself feeling comfortable during the night.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
14/06
No data
15/06
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Today
No data
17/06
US$327
18/06
No data
19/06
No data
20/06
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21/06
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busbud logoThe cheapest trip from Des Moines to San Diego was searched and found on 17 Jun 2025 with a price of US$327

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to San Diego as early as possible.

You can expect to pay from US$327 to US$327 for a bus ticket from Des Moines to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at US$327, which is on 2025-06-17.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Des Moines and San Diego!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Des Moines to San Diego, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to San Diego that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Des Moines to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Des Moines by bus?

Bus from Des Moines to San Diego

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