Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Columbus (E Mound St) | 1116 Woodruff Rd | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 100 E Rich St | 1116 Woodruff Rd | No tags | ||||
| Bus | Columbus (E Mound St) | 1116 Woodruff Rd | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Columbus (E Mound St) | 1116 Woodruff Rd | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Columbus (E Mound St) | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Last Tuesday at 16:25 EST.
Get from Columbus to Greenville
The journey takes about 21 hours 30 minutes, and with fares starting at just £93, it presents an excellent value for a comfortable ride.
Where are the popular stops in Columbus and Greenville?
Stops in Columbus
- A
Columbus Bus Station
25 E Rich St, Columbus, OH 43205, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Frequently asked questions about travelling by bus from Columbus, OH to Greenville, SC
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Columbus to Greenville?
The cheapest coach tickets from Columbus to Greenville start from £93. The average price for this route is around £100. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Columbus to Greenville?
The average bus journey time from Columbus to Greenville is 21h 30m, covering a distance of 356 miles. The fastest bus can take you there in 13h 45m and is operated by Greyhound.
Which bus companies service the Columbus to Greenville route?
What is the earliest and latest departure time for the bus from Columbus to Greenville?
The earliest bus departs from Columbus to Greenville at 00:50. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Columbus to Greenville?
A bus journey from Columbus to Greenville produces an estimated 14 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Columbus to Greenville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which company has the best Wi-Fi from Columbus to Greenville?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Columbus to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Columbus to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Columbus, OH to Greenville, SC was searched and found on 5 Jan 2026 with a price of £78To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Greenville, SC as early as possible.
You can expect to pay from £78 to £105 for a bus ticket from Columbus, OH to Greenville, SC based on the last 1 days. You can expect to find the cheapest price for the trip at £78, which is on 2026-01-05.
