Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Estacion Bimodal | São Paulo | CheapestFastest |
Last refresh of the prices: Last Wednesday at 11:48 AM -04.
Get from Santa Cruz de la Sierra to São Paulo
The journey takes about 1 day, 13 hours, and with fares starting at just $296, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santa Cruz de la Sierra and São Paulo?
Stops in Santa Cruz de la Sierra
- AAv Intermodal, Santa Cruz de la Sierra, Bolivia
Stops in São Paulo
- ATerminal Rodoviário da Barra Funda, Avenida Auro Soares de Moura Andrade, 664 - Barra Funda, São Paulo - SP, 01156-001, Brazil
- CTerminal Intermunicipal do Jabaquara, Rua dos Jequitibás, 80 - Jabaquara, São Paulo - SP, 04321-090
- D
Praça do Patriarca
Praça do Patriarca 78, Centro, São Paulo - SP, Brazil - E
São Paulo
São Paulo - F
Tietê
Terminal Rodoviário do Tietê, Avenida Cruzeiro do Sul, , 1800 Santana , 02030-000 São Paulo, SP
Compare bus companies
According to 15 reviews, La Preferida Bus received a 2.3-star rating for this journey. Travellers were especially satisfied with the seats and the temperature, but some complained about the ticket access. La Preferida Bus ticket prices on this trip start at $296
La Preferida Bus Santa Cruz de la Sierra São Paulo recent customer reviews
Not a good bus company. Late departures and arrivals, AC on bus leaked so had to be stopped midway through trip. Adding to this they don’t offer any help at all at border crossing between bolivia and Brasil. They sold us ‘direct’ tickets from Santa Cruz to São Paulo knowing there were issues at the border cross... we ended up missing the bus due to large lines and taking an extra day To finish the journey as the bus didn’t wait for any of the people attempting to cross the border and we had to leave it till the next day. Very disappointed with this company and for sure won’t use it again
Miguel E.
It was worst bus service in my experience. I booked la preferida. But actually I took different bus company, different timelines, different seat. I was confused, but they were not polite,so no explanation. I never use and recommend this company.
Akiko K.
Please installation wifi
Sungbin H.
Frequently asked questions about travelling from Santa Cruz de la Sierra, BO to São Paulo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Cruz de la Sierra to São Paulo?
The cheapest bus tickets from Santa Cruz de la Sierra to São Paulo start from $296. The average price for this route is around $414. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Cruz de la Sierra to São Paulo?
The average bus travel time from Santa Cruz de la Sierra to São Paulo is 1d 13h, covering a distance of 1833 km. The quickest bus can get you there in 1d 13h and is operated by La Preferida Bus.
Which bus companies service the Santa Cruz de la Sierra to São Paulo route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Santa Cruz de la Sierra to São Paulo?
The earliest bus departs from Santa Cruz de la Sierra to São Paulo at 8:30pm. And the latest bus departs at 8:30pm.
What are the CO₂ emissions for the bus trip from Santa Cruz de la Sierra to São Paulo?
A bus trip from Santa Cruz de la Sierra to São Paulo generates an estimated 46 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Cruz de la Sierra, BO to São Paulo was searched and found on Nov 26, 2025 with a price of $281To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Cruz de la Sierra, BO to São Paulo, as early as possible.
You can expect to pay from $281 to $427 for a bus ticket from Santa Cruz de la Sierra, BO to São Paulo based on the last 2 days. You can expect to find the cheapest price for the trip at $281 which is on 2025-11-30.
Top travelled bus routes
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