Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Terminál | Hotelu Grand | Cheapest | |||||
RegioJet + RegioJet | Terminál | Hlavní nádraží | Fastest | |||||
 | Terminál | Hotelu Grand | No tags | |||||
| Terminál | Hotelu Grand | No tags | |||||
| Terminál | Hotelu Grand | No tags |
Last refresh of the prices: Yesterday at 6:22 PM CET.
Get from Karlovy Vary to Brno
The journey takes about 5 hours 55 minutes, and with fares starting at just $19, it presents an excellent value for a comfortable ride.
Where are the popular stops in Karlovy Vary and Brno?
Stops in Karlovy Vary
- AZápadní 2080/2A, 360 01 Karlovy Vary, Czech Republic
- B
Tržnice
Varšavská 1275/5, 360 01 Karlovy Vary, Czech Republic
Stops in Brno
- ABenešova 603/2, Brno-město, 602 00 Brno-Brno-střed, Czech Republic
- BZvonařka 411, Trnitá, 602 00 Brno-Brno-střed, Czech Republic
- CNádražní 418/1, Brno-město, 602 00 Brno-Brno-střed, Czechia
- DBrno Bus Station, ÚAN Zvonařka, 602 00 Brno-střed, Czechia
- E
Ústřední hřbitov
Vídeňská 306/94, Štýřice, 639 00 Brno-Brno-střed, Czechia - F
Vídeňská 98
Vídeňská 98, 619 00 Brno-jih, Czechia
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Frequently asked questions about travelling from Karlovy Vary to Brno by bus
How far is Karlovy Vary from Brno?
It's about 293 km (182 miles) from Karlovy Vary to Brno.
What are the departure and arrival locations for buses traveling from Karlovy Vary to Brno?
Buses traveling this route start their trip at Terminál, in Karlovy Vary, and end it at Hotelu Grand, in Brno.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Karlovy Vary to Brno was searched and found on Nov 27, 2025 with a price of $15To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlovy Vary to Brno, as early as possible.
You can expect to pay from $15 to $52 for a bus ticket from Karlovy Vary to Brno based on the last 2 days. You can expect to find the cheapest price for the trip at $26 which is on 2025-12-02.
