Bus Tickets from Greenville, SC to Indianapolis

Previously seen trips

Next departures for Greenville to Indianapolis on November 14
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Bus
1116 Woodruff Rd
Indianapolis Bus StationNo tags
Greyhound + FlixBus
Bus
1116 Woodruff Rd
Downtown Transit CenterNo tags
FlixBus + Greyhound
Bus
1116 Woodruff Rd
Downtown Transit CenterNo tags
GreyhoundBus
1116 Woodruff Rd
Indianapolis Bus StationNo tags
Greyhound + FlixBus
Bus
1116 Woodruff Rd
Indianapolis Bus StationNo tags

Compare 2 ways to go from Greenville to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 17 hours 40 minutes, and with fares starting at just $116, it presents an excellent value for a comfortable ride.

6bus per day
17h 40mAverage Duration
646 kmDistance
16kgCO₂ emissions
Bus
Average Price$116 - $264Average Duration17h 40m
16kg CO₂e
Train
Average Price$252 - $1,904Average Duration1d 2h
58kg CO₂e

Frequently asked questions about travelling from Greenville, SC to Indianapolis by bus

  1. How far is Greenville from Indianapolis?

    The distance covered from Greenville to Indianapolis is 641 km (398 miles).

  2. What are the departure and arrival locations for buses traveling from Greenville to Indianapolis?

    Buses traveling this route start their trip at Guadalajara Supermarket Bus Stop, in Greenville, and end it at Greyhound Amtrak Station, in Indianapolis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11-11
No data
11-12
$188
Today
No data
11-14
$144
11-15
No data
11-16
No data
11-17
$121
11-18
No data
busbud logoThe cheapest trip from Greenville, SC to Indianapolis was searched and found on Nov 17, 2025 with a price of $121

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis, as early as possible.

You can expect to pay from $121 to $188 for a bus ticket from Greenville, SC to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $121 which is on 2025-11-17.

What's the cheapest way to go from Greenville, SC to Indianapolis?

busbud logoThe bus is the cheapest travel choice for this destination

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